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1996-03-09
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Document 0288
DOCN M9650288
TI Clinical spectrum of herpes zoster in adults infected with human
immunodeficiency virus.
DT 9605
AU Glesby MJ; Moore RD; Chaisson RE; Department of Medicine, Johns Hopkins
University, School of; Medicine, Baltimore, Maryland 21205, USA.
SO Clin Infect Dis. 1995 Aug;21(2):370-5. Unique Identifier : AIDSLINE
MED/96002792
AB To determine the incidence and clinical manifestations of herpes zoster
in a hospital-based clinic for adults infected with human
immunodeficiency virus (HIV), we reviewed the records of all patients
for whom zoster was diagnosed at or after their first clinic visit.
Fifty-two episodes of zoster occurred in 45 patients during 1,614
person-years of follow-up (incidence, 3.2 episodes per 100
person-years). The following major complications of zoster occurred in
12 patients (27%): ocular complications (5), neurological complications
(4), and chronic atypical skin lesions (5). Six patients each had
postherpetic neuralgia and bacterial superinfection, which were the
common minor complications of zoster. Multivariate analysis revealed
that only a low CD4 cell count (< or = 200/mm3) was predictive of a
major complication of zoster (OR, 13.2; 95% CI, 1.52-114; P = .019).
Thus, complications of herpes zoster are common in patients with HIV
infection, especially those with advanced immunosuppression.
DE Adult Ambulatory Care Facilities Baltimore/EPIDEMIOLOGY Cohort
Studies CD4 Lymphocyte Count Female Follow-Up Studies Herpes
Zoster/DIAGNOSIS/*EPIDEMIOLOGY/ETIOLOGY Human HIV
Infections/*COMPLICATIONS/IMMUNOLOGY *HIV-1 Incidence Male Middle
Age Recurrence Retrospective Studies Risk Factors Support, U.S.
Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).